Formal Genetics of Humans: Multifactorial Inheritance and Common Diseases
نویسندگان
چکیده
8.1.1 Variation in Phenotypic Traits ................................. 264 8.1.2 Familial Resemblance and Heritability ................... 264 8.1.3 The Special Case of Twins ...................................... 267 8.1.4 Embedding a Single Measured Gene Infl uencing a Continuous Trait ................................ 269 8.1.5 A Model for Variance Partitioning .......................... 269 8.1.6 Relating the Model to Data...................................... 270 8.1.7 Mendelian Diseases Are Not Simple ....................... 271
منابع مشابه
Evolving methods in genetic epidemiology. I. Analysis of genetic and environmental factors in family studies.
Using family data (either sibships, nuclear families, or extended pedigrees) to test models of inheritance is the essence of human genetics. The rigor and precision of this testing process can range from a strictly observational process (eliminating simple single-locus models one at a time on individual pedigrees) through formal tests of hypotheses about the expected proportion of affected sibs...
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